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Science

Don't take our word for it - the proof is in the science. It actually works and is backed by science. 1000+ scientific papers demonstrate the anti-aging, pore minimizing, natural plumping effects of bee venom. Randomized, double-blinded trials have also demonstrated the muscle-relaxing effects of bee venom after skin application. 

The benefits of bee venom don't stop there: For years, bee venom has been used throughout Asia as an alternative medicine to treat rheumatoid arthritis and pain. More recently, research shows that bee venom applied topically to the skin improves acne as an antimicrobial, eczema (atopic dermatitis), psoriasisinflammation, fibrosis, wound healing, hair loss, and has anti-cancer effects. It even shows inhibitory effects against viruses in the lab and in humans.

Bee Venom Benefits

Anti-aging: increases skin cell regeneration, stimulates collagen production

Muscle & pain: relaxes muscles and inhibits pain signal pathways

Anti-bacterial: improves acne

Anti-fungal: shown improvement in fungal infections of skin

Anti-viral: demonstrates inhibitory effects against viruses

Anti-inflammatory: decreases skin inflammation and redness

Wound healing: increases cell turnover and promotes wound healing

Improvement in skin conditions: atopic dermatitis (eczema) & psoriasis

Anti-cancer effects: suppresses tumor signal pathways

 

Scientific Research & Clinical Trials

Anti-Aging:

  • Evaluation of the skin phototoxicity and photosensitivity of honeybee venom. Journal of Cosmetic Dermatology, 2017. Han SM, Hong IP, Woo SO, et al.
  • The beneficial effects of honeybee-venom serum on facial wrinkles in human. Clinical Interventions & Aging, 2015. Han SM, Hong IP, Woo SO, et al.
  • Inhibitory effect of bee venom against ultraviolet B induced MMP-1 and MMP-3 in human dermal fibroblasts. Journal of Apicultural Research, 2007. Han SM, Lee KG, Yeo JH, et al.
  • Anti-wrinkle effect of pla2-free bee venom against uvb-irradiated human skin cells. Journal of Agriculture & Life Sciences, 2015. Lee H, Bae SK, Pyo M, et al.
  • Bee venom stimulates human melanocyte proliferation, melanogenesis, dendricity and migration. Experimental Molecular Medicine, 2007. Jeon S, Kim NH, Koo BS, et al.
  • Potential therapeutic applications of bee venom on skin diseases and its mechanisms: A literature review. Toxins, 2019. Kim H, Park SY, Lee G.
  • Bee products in dermatology and skin care. Molecules, 2020. Kurek-Gorecka A, Gorecki M, Rzepecka-Stojko A, et al.
  • Bee venom therapy: Potential mechanisms and therapeutic applications. Toxicon, 2018. Zhang S, Liu Y, Ye Y, et al.

Muscle Relaxation:

  • Myorelaxant effect of bee venom topical skin application in patients with RDC/TMD 1a and RDC/TMB 1b: a randomized, double blinded study. BioMed Research International, 2014. Nitecha-Buchta A, Buchta P, Tabenska-Bosakowska E, et al.
  • Bee venom acupuncture for musculoskeletal pain: A review. Journal of Pain, 2008. Lee MS, Pittler MH, Shin BC, et al.
  • Bee venom acupuncture for the treatment of chornic low back pain: Study protocol for randomized, double-blinded, sham-controlled trial. Trials, 2013. Seo BK, Lee JH, Sung WS, et al.

Acne Treatment/Anti-Bacterial:

  • Antibacterial and anti-inflammatory effects of honeybee (Apis mellifera) venom against acne-inducing bacteria. Journal of Medicine & Plant Research, 2010. Han SM, Lee KG, Yeo JK, et al.
  • Melittin, a honeybee venom-derived antimicrobial peptide, may target methicillin-resistant Staphylococcus aureus. Molecular Medicine Reports, 2015. Kim JY, Lee WR, Kim KH.
  • Complementary therapies for acne vulgaris. Cochrane Database of Systematic Reviews, 2015. Cao H, Yang G, Want Y, et al.
  • Inhibitory effects of bee venom on Propionibacterium acnes-induced inflammatory skin disease in an animal model. International Journal of Molecular Medicine, 2014. An HJ, Lee WR, Kim HG.
  • SPINK9 stimulates metalloprotease/EGFR-dependent keratinocyte migration via purinergic receptor activation. Journal of Investigative Dermatology, 2014. Sperrhacke M, Fischer J, Wu Z, et al.
  • Effects of cosmetics containing purified honeybee (Apis Mellifera L.) venom on acne vulgaris. Journal of Integrated Medicine, 2013. Han SM, Lee KG, Pak SC.
  • Bee venom (apis mellifera) an effective potential alternative to gentamicin for specific bacteria strains: Bee venom an effective potential for bacteria.Journal of Pharmacopuncture, 2016. Zolfagharian H, Mohajeri M, Babaie M.
  • Antibacterial activity and antibiotic-enhancing effects of honeybee venom against methicillin-resistant staphylococcus aureus. Molecules, 2016. Han SM, Kim JM, Hong IP.
  • Antimicrobial activity of bee venom and melittin against borrelia burgdorferi. Antibiotics, 2017. Socarras KM, Theophilus PAS, Torres JP, et al.
  • Evaluation of anti-acne property of purified bee venom serum in humans. Journal of Cosmetic Dermatology. 2016. Han SM, Pak SC, Nicholls YM, et al.

Anti-Viral:

  • Inhibitory effects of bee venom and its components against viruses in vitro and in vivo. Journal of Microbiology, 2016. Uddin MB, Lee BH, Nikapitiya C, et al.

Anti-Fungal:

  • Biochemistry: The antifungal activity of bee venom against dermatophytes. Journal of Applied Biology & Chemistry, 2012. Yu AR, Kim JJ, Park GS, et al.
  • Antifungal effects of bee venom components on trichophyton rubrum: A novel approach of bee venom study for possible emerging antifungal agent. Annals of Dermatology, 2018. Park J, Kwon O, An HJ, et al.
  • Antifungal activity of bee venom and sweet bee venom against clinically isolated candida albicans.Journal of Pharmacopuncture.  Lee SB.
  • Melittin induces apoptotic features in candida albicans. Biochemical & Biophysical Research Communications, Park C, Lee DG.
  • Apis cerana bee venom: It’s antidiabetic and anti-dandruff activity against malassezia furfur.World Applied Sciences Journal,  Prakash S, Bhargava H.

Anti-Inflammatory

  • Anti-inflammatory effect of bee venom in phthalic anhydride-induced atopic dermatitis animal model. Inflammopharmacology, 2020. Lee YJ, Oh MJ, Lee DH, et al.
  • Anti-inflammatory applications of melittin, a major component of bee venom: Detailed mechanism of action and adverse effects. Molecules, 2016. Lee G, Bae H.
  • The protective effect of bee venom on fibrosis causing inflammatory diseases. Toxins, 2015. Lee WR, Pak SC, Park KK.
  • Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds. Pharmacological Therapy, 2007. Son DJ, Lee JW, Lee YH, et al.  
  • Antibacterial and anti- inflammatory effects of honeybee (Apis mellifera) venom against acne-inducing bacteria. Journal of Medicinal Plant Research, 2010. Han SM, Lee KG, Yeo JH, et al.
  • Bee venom acupuncture for rheumatoid arthritis: A systematic review of randomised clinical trials. British Medical Journal, 2014. Lee JA, Son MJ, Choi J, et al.

Atopic Dermatitis (Eczema) Treatment:

  • Therapeutic effects of bee venom and its major component, melittin, on atopic dermatitis in vivo and in vitro. British Journal of Pharmacology, 2018. An HJ, Kim JY, Kim WH.
  • Bee venom alleviates atopic dermatitis symptoms through the upregulation of decay-accelerating factor (DAF/CD55). Toxins, 2019. Kim Y, Lee YW, Kim H, et al.
  • Therapeutic effects of bee venom on experimental atopic dermatitis. Molecular Medicine Reports, 2018. Gu H, Kim WH, An HJ, et al.
  • Bee venom phospholipase A2 alleviate house dust mite-induced atopic dermatitis-like skin lesions by the CD206 mannose receptor. Toxins, 2018. Shin D, Choi W, Bae H.
  • Beneficial effects of melittin on ovalbumin-induced atopic dermatitis in mouse. Scientific Reports, 2017. Kim WH, An HJ, Kim JY, et al.
  • Effects of emollient containing bee venom on atopic dermatitis: A double-blinded, randomized, base-controlled, multicenter study of 136 patients. Annals of Dermatology, 2016. You CE, Moon SH, Lee KH, et al.
  • Bee venom ameliorates compound 48/80-induced atopic dermatitis-related symptoms. International Journal of Clinical and Experimental Pathology, 2013. Kim KH, Lee WR, An HJ, et al.

Psoriasis Treatment:

  • Is there a place for local naural treatment of psoriasis? Open Access Macedonian Journal of Medical Sciences, 2018. El-Gammal A, Nardo VD, Daaboul F, et al.
  • Honey and bee venom in dermatology: A novel possible alternative or complimentary therapy for psoriasis vulgaris. Ancient Science of Life, 2014. Senel E, Kuyucu M, Suslu I.
  • Efficacy of the apitherapy in the treatment of recalcitrant localized plaque psoriasis and evaluation of tumor necrosis factor-alpha (TNF-alpha) serum level: A double-blind randomized clinical trial. Journal of Dermatological Treatment, 2015. Eltaher S, Mohammed GF, Younes S, et al.
  • Bee venom and propolis as new treatment modality in patients with localized plaque psoriasis. International Research Journal of Medicine and Medical Sciences, 2013. Hegazi AG, Raboh FAA, Famzy NE, et al.

Wound Healing:

  • Phospholipase A2 from bee venom increases poly(I:C)-induced activation in human keratocytes. International Immunology, 2020. Nakashima A, Tomono S, Yamazaki T, et al.
  • Bee venom accelerates wound healing in diabetic mice by suppressing activating transcription factor-3 (ATF-3) and inducible nitric oxide synthase (iNOS)-medicated oxidative stress and recruiting bone marrow-derived endothelial progenitor cells. Journal of Cell Physiology, 2016. Badr G, Hozzein WN, Badr BM, et al.
  • Biological effects of treatment of an animal skin wound and honeybee (Apis mellifera L) venom. Journal of Plastic and Reconstructive Aesthetic Surgery, 2011. Han SM, Lee KG, Yeo JH, et al.
  • Melittin has a chondroprotective effect by inhibiting MMP-1 and MMP-8 expressions via blocking NF-kappaB and AP-1 signaling pathway in chondrocytes. International Immunopharmacology, 2015. Jeong YJ, Shin JM, Bae YS, et al.
  • Accelerated wound healing and anti-inflammatory effects of physically cross linked polyvinyl alcohol-chitosan hydrogel containing honey bee venom in diabetic rats. Archives of Pharmacological Research, 2014. Amin MA, Abdel-Raheem IT.
  • Bee venom improves diabetic wound healing by protecting functional macrophages from apoptosis and enhancing nrf2, ang-1 and tie-2 signaling. Molecular Immunology, 2018. Hozzein WN, Badr G, Badr BM, et al.

Anti-Cancer:

  • Bee venom and its peptide component melittin suppress growth and migration of melanoma cells via inhibition of PI3K/AKT/mTOR and MAPK pathways. Molecules, 2019. Ln HN, Baek SB, Jung HJ.
  • Anti-cancer effect of bee venom on colon cancer cell growth by activation of death receptors and inhibition of nuclear factor kappa B. Oncotarget, 2015. Zheng J, Lee HL, Ham YW, et al.
  • Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds. Pharmacological Therapy, 2007. Son DJ, Lee JW, Song HS, et al.
  • Anti-tumor effects of melittin and its potential applications in clinic. Current Protein & Peptide Science, 2019. Lyu C, Fang F, Li B.
  • Melittin, a major peptide component of bee venom, and its conjugates in cancer therapy. Cancer Letters, 2017. Rady I, Siddiqui IA, Rady M, et al.
  • Honeybee venom induces calcium-dependent but caspase-independent apoptotic cell death in human melanoma a2058 cells. Toxicon, 2008. Tu WC, Wu CC, Hsieh HL, et al.

Hair Growth:

  • Bee venom promotes hair growth in association with inhibiting 5alpha-reductase expression.Biological and Pharmaceutical Bulletin, 2016. Park S, Erdogan S, Hwang D.